abstract：:The tetraspanins are a superfamily of transmembrane proteins with diverse functions and can form extended microdomains within the plasma membrane in conjunction with partner proteins, which probably includes receptors for bacterial adhesins. Neisseria meningitidis, the causative agent of meningococcal disease, attache...

journal_title：Infection and immunity

authors： Green LR,Monk PN,Partridge LJ,Morris P,Gorringe AR,Read RC

更新日期：2011-06-01 00:00:00

abstract：:The mechanisms that govern the initial interaction between Paracoccidioides brasiliensis, a primary dimorphic fungal pathogen, and cells of the innate immunity need to be clarified. Our previous studies showed that Toll-like receptor 2 (TLR2) and TLR4 regulate the initial interaction of fungal cells with macrophages a...

journal_title：Infection and immunity

authors： Loures FV,Pina A,Felonato M,Feriotti C,de Araújo EF,Calich VL

更新日期：2011-06-01 00:00:00

abstract：:Assembly of adherent biofilms is the key mechanism involved in Staphylococcus epidermidis virulence during device-associated infections. Aside from polysaccharide intercellular adhesin (PIA), the accumulation-associated protein Aap and the extracellular matrix binding protein Embp act as intercellular adhesins, mediat...

journal_title：Infection and immunity

authors： Schommer NN,Christner M,Hentschke M,Ruckdeschel K,Aepfelbacher M,Rohde H

更新日期：2011-06-01 00:00:00

abstract：:CD8(+) T lymphocytes often play a primary role in adaptive immunity to cytosolic microbial pathogens. Surprisingly, CD8(+) T cells are not required for protective immunity to the enteric pathogen Shigella flexneri, despite the ability of Shigella to actively secrete proteins into the host cytoplasm, a location from wh...

journal_title：Infection and immunity

authors： Jehl SP,Doling AM,Giddings KS,Phalipon A,Sansonetti PJ,Goldberg MB,Starnbach MN

更新日期：2011-05-01 00:00:00

abstract：:NF-κB is a critical regulator of gene expression during severe infections. NF-κB comprises homo- and heterodimers of proteins from the Rel family. Among them, p50 and p65 have been clearly implicated in the pathophysiology of sepsis. In contrast, the role of cRel in sepsis is still controversial and has been poorly st...

journal_title：Infection and immunity

authors： Courtine E,Pène F,Cagnard N,Toubiana J,Fitting C,Brocheton J,Rousseau C,Gerondakis S,Chiche JD,Ouaaz F,Mira JP

更新日期：2011-05-01 00:00:00

abstract：:Rhodococcus equi is an intracellular pathogen which causes pneumonia in young horses and in immunocompromised humans. R. equi arrests phagosome maturation in macrophages at a prephagolysosome stage and grows inside a privileged compartment. Here, we show that, in murine macrophages activated with gamma interferon and ...

journal_title：Infection and immunity

authors： von Bargen K,Wohlmann J,Taylor GA,Utermöhlen O,Haas A

更新日期：2011-05-01 00:00:00

abstract：:Candida albicans is a common opportunistic fungal pathogen and is the leading cause of invasive fungal diseases in immunocompromised individuals. The induction of cell-mediated immunity to C. albicans is one of the main tasks of cells of the innate immune system, and in vitro evidence suggests that integrin α(M)β₂ (CR...

journal_title：Infection and immunity

authors： Soloviev DA,Jawhara S,Fonzi WA

更新日期：2011-04-01 00:00:00

abstract：:The plasma level of the chemokine CCL3 is elevated in patients with chronic severe schistosomiasis mansoni. We have previously shown that CCL3(-/-) mice with experimental infection showed diminished pathology and worm burden compared to those of wild-type (WT) mice. To elucidate further the role of CC chemokines durin...

journal_title：Infection and immunity

authors： Souza AL,Souza PR,Pereira CA,Fernandes A,Guabiraba R,Russo RC,Vieira LQ,Corrêa A Jr,Teixeira MM,Negrão-Corrêa D

更新日期：2011-04-01 00:00:00

abstract：:Pneumonic tularemia is a life-threatening disease caused by inhalation of the highly infectious intracellular bacterium Francisella tularensis. The most serious form of the disease associated with the type A strains can be prevented in experimental animals through vaccination with the attenuated live vaccine strain (L...

journal_title：Infection and immunity

authors： Mara-Koosham G,Hutt JA,Lyons CR,Wu TH

更新日期：2011-04-01 00:00:00

abstract：:Spotted fever group rickettsiae are known to produce distinct plaque phenotypes. Strains that cause lytic infections in cell culture form clear plaques, while nonlytic strains form opaque plaques in which the cells remain intact. Clear plaques have historically been associated with more-virulent species or strains of ...

journal_title：Infection and immunity

authors： Clark TR,Ellison DW,Kleba B,Hackstadt T

更新日期：2011-04-01 00:00:00

abstract：:Leptospirosis can activate inflammatory responses through Toll-like receptors (TLRs) and may cause renal tubulointerstitial fibrosis characterized by the accumulation of extracellular matrix (ECM). We have previously demonstrated that Leptospira santorosai serovar Shermani detergent extract stimulates ECM accumulation...

journal_title：Infection and immunity

authors： Tian YC,Hung CC,Li YJ,Chen YC,Chang MY,Yen TH,Hsu HH,Wu MS,Phillips A,Yang CW

更新日期：2011-03-01 00:00:00

abstract：:Streptococcus pneumoniae is a major cause of pneumonia and meningitis. Airway colonization is a necessary precursor to disease, but little is known about how the bacteria establish and maintain colonization. Carbohydrates are required as a carbon source for pneumococcal growth and, therefore, for colonization. Free ca...

journal_title：Infection and immunity

authors： Marion C,Burnaugh AM,Woodiga SA,King SJ

更新日期：2011-03-01 00:00:00

abstract：:Cholera toxin (CT) is a potent adjuvant for mucosal vaccination; however, its mechanism of action has not been clarified completely. It is well established that peripheral monocytes differentiate into dendritic cells (DCs) both in vitro and in vivo and that monocytes are the in vivo precursors of mucosal CD103(-) proi...

journal_title：Infection and immunity

authors： Veglia F,Sciaraffia E,Riccomi A,Pinto D,Negri DR,De Magistris MT,Vendetti S

更新日期：2011-03-01 00:00:00

abstract：:We previously demonstrated that plasmid-deficient Chlamydia muridarum retains the ability to infect the murine genital tract but does not elicit oviduct pathology because it fails to activate Toll-like receptor 2 (TLR2). We derived a plasmid-cured derivative of the human genital isolate Chlamydia trachomatis D/UW-3/Cx...

journal_title：Infection and immunity

authors： O'Connell CM,AbdelRahman YM,Green E,Darville HK,Saira K,Smith B,Darville T,Scurlock AM,Meyer CR,Belland RJ

更新日期：2011-03-01 00:00:00

abstract：:Invasive aspergillosis is a major threat for patients suffering from chronic granulomatous disease (CGD). Although Aspergillus fumigatus is the most commonly encountered Aspergillus species, the presence of A. nidulans appears to be disproportionately high in CGD patients. The purpose of this study was to investigate ...

journal_title：Infection and immunity

authors： Henriet SS,Hermans PW,Verweij PE,Simonetti E,Holland SM,Sugui JA,Kwon-Chung KJ,Warris A

更新日期：2011-02-01 00:00:00

abstract：:Carbon storage regulator A (CsrA) is an RNA binding protein that has been characterized in many bacterial species to play a central regulatory role by modulating several metabolic processes. We recently showed that a homolog of CsrA in Borrelia burgdorferi (CsrA(Bb), BB0184) was upregulated in response to propagation ...

journal_title：Infection and immunity

authors： Karna SL,Sanjuan E,Esteve-Gassent MD,Miller CL,Maruskova M,Seshu J

更新日期：2011-02-01 00:00:00

abstract：:Subtilase cytotoxin (SubAB), which is produced by certain strains of Shiga-toxigenic Escherichia coli (STEC), causes the 78-kDa glucose-regulated protein (GRP78/BiP) cleavage, followed by induction of endoplasmic reticulum (ER) stress, leading to caspase-dependent apoptosis via mitochondrial membrane damage by Bax/Bak...

journal_title：Infection and immunity

authors： Yahiro K,Satoh M,Morinaga N,Tsutsuki H,Ogura K,Nagasawa S,Nomura F,Moss J,Noda M

更新日期：2011-02-01 00:00:00

abstract：:Yersinia pestis is a highly pathogenic Gram-negative organism and the causative agent of bubonic and pneumonic plague. Y. pestis is capable of causing major epidemics; thus, there is a need for vaccine targets and a greater understanding of the role of these targets in pathogenesis. Two prime Y. pestis vaccine candida...

journal_title：Infection and immunity

authors： Weening EH,Cathelyn JS,Kaufman G,Lawrenz MB,Price P,Goldman WE,Miller VL

更新日期：2011-02-01 00:00:00

abstract：:Tick saliva has potent immunomodulatory properties. In arthropod-borne diseases, this effect is largely used by microorganisms to increase their pathogenicity and to evade host immune responses. We show that in Lyme borreliosis, tick salivary gland extract and a tick saliva protein, Salp15, inhibit in vitro keratinocy...

journal_title：Infection and immunity

authors： Marchal C,Schramm F,Kern A,Luft BJ,Yang X,Schuijt TJ,Hovius JW,Jaulhac B,Boulanger N

更新日期：2011-02-01 00:00:00

abstract：:Staphylococcus aureus is a prominent human pathogen and a leading cause of community- and hospital-acquired bacterial infections worldwide. Herein, we describe the identification and characterization of the S. aureus 67.6-kDa hypothetical protein, named for the surface factor promoting resistance to oxidative killing ...

journal_title：Infection and immunity

authors： Malachowa N,Kohler PL,Schlievert PM,Chuang ON,Dunny GM,Kobayashi SD,Miedzobrodzki J,Bohach GA,Seo KS

更新日期：2011-01-01 00:00:00

abstract：:Smoking is associated with increased susceptibility to tuberculosis and influenza. However, little information is available on the mechanisms underlying this increased susceptibility. Mice were left unexposed or were exposed to cigarette smoke and then infected with Mycobacterium tuberculosis by aerosol or influenza A...

journal_title：Infection and immunity

authors： Feng Y,Kong Y,Barnes PF,Huang FF,Klucar P,Wang X,Samten B,Sengupta M,Machona B,Donis R,Tvinnereim AR,Shams H

更新日期：2011-01-01 00:00:00

abstract：:The human gastric pathogen Helicobacter pylori modifies host cholesterol via glycosylation and incorporates the glycosylated cholesterol into its membrane; however, the benefits of cholesterol to H. pylori are largely unknown. We speculated that cholesterol in the H. pylori membrane might alter the susceptibility of t...

journal_title：Infection and immunity

authors： Trainor EA,Horton KE,Savage PB,Testerman TL,McGee DJ

更新日期：2011-01-01 00:00:00

abstract：:Chlamydia trachomatis infections can lead to severe chronic complications, including trachoma, ectopic pregnancy, and infertility. The only effective approach to disease control is vaccination. The goal of this work was to identify new potential vaccine candidates through a proteomics approach. We constructed a protei...

journal_title：Infection and immunity

authors： Cruz-Fisher MI,Cheng C,Sun G,Pal S,Teng A,Molina DM,Kayala MA,Vigil A,Baldi P,Felgner PL,Liang X,de la Maza LM

更新日期：2011-01-01 00:00:00

abstract：:In the enteric pathogen Vibrio cholerae, expression of the major virulence factors is controlled by the hierarchical expression of several regulatory proteins comprising the ToxR regulon. In this study, we demonstrate that disruption of the fadD gene encoding a long-chain fatty acyl coenzyme A ligase has marked effect...

journal_title：Infection and immunity

authors： Ray S,Chatterjee E,Chatterjee A,Paul K,Chowdhury R

更新日期：2011-01-01 00:00:00

abstract：:Thirty percent of Streptococcus pneumoniae isolates contain pilus islet 1, coding for a pilus composed of the backbone subunit RrgB and two ancillary proteins, RrgA and RrgC. RrgA is the major determinant of in vitro adhesion associated with pilus 1, is protective in vivo in mouse models, and exists in two variants (c...

journal_title：Infection and immunity

authors： Moschioni M,Emolo C,Biagini M,Maccari S,Pansegrau W,Donati C,Hilleringmann M,Ferlenghi I,Ruggiero P,Sinisi A,Pizza M,Norais N,Barocchi MA,Masignani V

更新日期：2010-12-01 00:00:00

abstract：:Understanding the regulation of human immune responses is critical for vaccine development and treating infectious diseases. We have previously shown that simultaneous engagement of the T cell receptor (TCR) and complement regulator CD46 on human CD4(+) T cells in the presence of interleukin-2 (IL-2) induces potent se...

journal_title：Infection and immunity

authors： Truscott SM,Abate G,Price JD,Kemper C,Atkinson JP,Hoft DF

更新日期：2010-12-01 00:00:00

abstract：:Little is known about Zn homeostasis in Yersinia pestis, the plague bacillus. The Znu ABC transporter is essential for zinc (Zn) uptake and virulence in a number of bacterial pathogens. Bioinformatics analysis identified ZnuABC as the only apparent high-affinity Zn uptake system in Y. pestis. Mutation of znuACB caused...

journal_title：Infection and immunity

authors： Desrosiers DC,Bearden SW,Mier I Jr,Abney J,Paulley JT,Fetherston JD,Salazar JC,Radolf JD,Perry RD

更新日期：2010-12-01 00:00:00

abstract：:The reproducibility of an experimental result is a fundamental assumption in science. Yet, results that are merely confirmatory of previous findings are given low priority and can be difficult to publish. Furthermore, the complex and chaotic nature of biological systems imposes limitations on the replicability of scie...

journal_title：Infection and immunity

authors： Casadevall A,Fang FC

更新日期：2010-12-01 00:00:00

abstract：:The multiple antigen peptide (MAP) approach is an effective method to chemically synthesize and deliver multiple T-cell and B-cell epitopes as the constituents of a single immunogen. Here we report on the design, chemical synthesis, and immunogenicity of three Plasmodium falciparum MAP vaccines that incorporated antig...

journal_title：Infection and immunity

authors： Mahajan B,Berzofsky JA,Boykins RA,Majam V,Zheng H,Chattopadhyay R,de la Vega P,Moch JK,Haynes JD,Belyakov IM,Nakhasi HL,Kumar S

更新日期：2010-11-01 00:00:00

abstract：:Subtilase cytotoxin (SubAB) was first isolated from a Shiga toxigenic Escherichia coli (STEC) strain that was responsible for an outbreak of hemolytic-uremic syndrome and is the prototype of a new family of AB(5) cytotoxins. SubAB is a subtilase-like serine protease, and upon uptake by host cells, it is trafficked to ...

journal_title：Infection and immunity

authors： May KL,Paton JC,Paton AW

更新日期：2010-11-01 00:00:00

abstract：:The secretion of aspartic proteases (Saps) has long been recognized as a virulence-associated trait of the pathogenic yeast Candida albicans. In this study, we report that different recombinant Saps, including Sap1, Sap2, Sap3, and Sap6, have differing abilities to induce secretion of proinflammatory cytokines by huma...

journal_title：Infection and immunity

authors： Pietrella D,Rachini A,Pandey N,Schild L,Netea M,Bistoni F,Hube B,Vecchiarelli A

更新日期：2010-11-01 00:00:00

abstract：:Candida albicans secreted aspartyl proteinases (Saps) are considered virulence-associated factors. Several members of the Sap family were claimed to play a significant role in the progression of candidiasis established by the hematogenous route. This assumption was based on the observed attenuated virulence of sap-nul...

journal_title：Infection and immunity

authors： Correia A,Lermann U,Teixeira L,Cerca F,Botelho S,da Costa RM,Sampaio P,Gärtner F,Morschhäuser J,Vilanova M,Pais C

更新日期：2010-11-01 00:00:00

abstract：:The Haemophilus ducreyi 35000HP genome encodes a homolog of the CpxRA two-component cell envelope stress response system originally characterized in Escherichia coli. CpxR, the cytoplasmic response regulator, was shown previously to be involved in repression of the expression of the lspB-lspA2 operon (M. Labandeira-Re...

journal_title：Infection and immunity

authors： Labandeira-Rey M,Brautigam CA,Hansen EJ

更新日期：2010-11-01 00:00:00

abstract：:Despite effective antimicrobial chemotherapy, control of Chlamydia trachomatis urogenital infection will likely require a vaccine. We have assessed the protective effect of an outer membrane protein-based vaccine by using a murine model of chlamydial genital infection. Female mice were first vaccinated with Chlamydia ...

journal_title：Infection and immunity

authors： Farris CM,Morrison SG,Morrison RP

更新日期：2010-10-01 00:00:00

abstract：:Catheter-associated urinary tract infections (CAUTIs) constitute the majority of nosocomial UTIs and pose significant clinical challenges. Enterococcal species are among the predominant causative agents of CAUTIs. However, very little is known about the pathophysiology of Enterococcus-mediated UTIs. We optimized a mur...

journal_title：Infection and immunity

authors： Guiton PS,Hung CS,Hancock LE,Caparon MG,Hultgren SJ

更新日期：2010-10-01 00:00:00

abstract：:Clostridium perfringens type A food poisoning is the second most commonly identified bacterial food-borne illness. Sporulation contributes to this disease in two ways: (i) most food-poisoning strains form exceptionally resistant spores to facilitate their survival of food-associated stresses, and (ii) the enterotoxin ...

journal_title：Infection and immunity

authors： Li J,McClane BA

更新日期：2010-10-01 00:00:00

abstract：:Pasteurella multocida is the causative agent of a number of diseases in animals, including fowl cholera. P. multocida strains simultaneously express two lipopolysaccharide (LPS) glycoforms (glycoforms A and B) that differ only in their inner core structure. Glycoform A contains a single 3-deoxy-d-manno-octulosonic aci...

journal_title：Infection and immunity

authors： Harper M,Cox AD,St Michael F,Ford M,Wilkie IW,Adler B,Boyce JD

更新日期：2010-09-01 00:00:00

abstract：:Neisseria meningitidis is a major cause of sepsis and meningitis but is also a common commensal, present in the nasopharynx of between 8 and 20% of healthy individuals. During carriage, the bacterium is found on the surface of the nasopharyngeal epithelium and in deeper tissues, while to develop disease the meningococ...

journal_title：Infection and immunity

authors： Sutherland TC,Quattroni P,Exley RM,Tang CM

更新日期：2010-09-01 00:00:00

abstract：:The orotidine-5'-monophosphate decarboxylase (OMPDC) gene, encoding the final enzyme of the de novo pyrimidine biosynthesis pathway, was deleted using Toxoplasma gondii KU80 knockouts to develop an avirulent nonreverting pyrimidine auxotroph strain. Additionally, to functionally address the role of the pyrimidine salv...

journal_title：Infection and immunity

authors： Fox BA,Bzik DJ

更新日期：2010-09-01 00:00:00

abstract：:This study focuses on the interaction of the three components of the Bacillus cereus Nhe enterotoxin with particular emphasis on the functional roles of NheB and NheC. The results demonstrated that both NheB and NheC were able to bind to Vero cells directly while NheA lacked this ability. It was also shown that Nhe-in...

journal_title：Infection and immunity

authors： Lindbäck T,Hardy SP,Dietrich R,Sødring M,Didier A,Moravek M,Fagerlund A,Bock S,Nielsen C,Casteel M,Granum PE,Märtlbauer E

更新日期：2010-09-01 00:00:00